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Research Article

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

  • Murat Cirit,

    Affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Matej Krajcovic,

    Affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Colin K. Choi,

    Affiliation: Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United States of America

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  • Erik S. Welf,

    Affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Alan F. Horwitz,

    Affiliation: Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United States of America

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  • Jason M. Haugh mail

    jason_haugh@ncsu.edu

    Affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.pcbi.1000688

About the Authors

Murat Cirit, Matej Krajcovic, Erik S. Welf, Jason M. Haugh
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America
Colin K. Choi, Alan F. Horwitz
Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United States of America

Corresponding Author

Email: jason_haugh@ncsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC MK CKC ESW AFH JMH. Performed the experiments: MC MK CKC. Analyzed the data: MC MK CKC ESW JMH. Wrote the paper: JMH.