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Research Article

Unfolding Simulations Reveal the Mechanism of Extreme Unfolding Cooperativity in the Kinetically Stable α-Lytic Protease

  • Neema L. Salimi,

    Affiliations: Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Bosco Ho,

    Affiliations: Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • David A. Agard mail

    agard@msg.ucsf.edu

    Affiliations: Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.pcbi.1000689

About the Authors

Neema L. Salimi
Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America
Neema L. Salimi, Bosco Ho, David A. Agard
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America
Neema L. Salimi, Bosco Ho, David A. Agard
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: agard@msg.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NLS DAA. Performed the experiments: NLS. Analyzed the data: NLS. Contributed reagents/materials/analysis tools: NLS. Wrote the paper: NLS BH DAA.