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Research Article

Interpreting Metabolomic Profiles using Unbiased Pathway Models

  • Rahul C. Deo,

    Affiliations: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Luke Hunter,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gregory D. Lewis,

    Affiliations: Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Guillaume Pare,

    Affiliations: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ramachandran S. Vasan,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Boston, Massachusetts, United States of America, Sections of Cardiology and Preventive Medicine, and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Daniel Chasman,

    Affiliations: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Thomas J. Wang,

    Affiliations: Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Boston, Massachusetts, United States of America

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  • Robert E. Gerszten,

    Affiliations: Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Frederick P. Roth mail

    fritz_roth@hms.harvard.edu

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.pcbi.1000692

About the Authors

Rahul C. Deo, Luke Hunter, Frederick P. Roth
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
Rahul C. Deo, Gregory D. Lewis, Thomas J. Wang, Robert E. Gerszten
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Gregory D. Lewis, Robert E. Gerszten
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Guillaume Pare, Daniel Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Guillaume Pare, Daniel Chasman
Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Ramachandran S. Vasan, Thomas J. Wang
Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Boston, Massachusetts, United States of America
Ramachandran S. Vasan
Sections of Cardiology and Preventive Medicine, and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America
Robert E. Gerszten
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: fritz_roth@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCD LH FPR. Performed the experiments: RCD LH. Analyzed the data: RCD LH GP DC. Contributed reagents/materials/analysis tools: GDL RSV TJW REG. Wrote the paper: RCD RSV DC TJW REG FPR.