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Research Article

Quantitative Comparison of Catalytic Mechanisms and Overall Reactions in Convergently Evolved Enzymes: Implications for Classification of Enzyme Function

  • Daniel E. Almonacid,

    Affiliations: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America

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  • Emmanuel R. Yera,

    Affiliation: Biological and Medical Informatics Graduate Program, University of California San Francisco, San Francisco, California, United States of America

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  • John B. O. Mitchell,

    Affiliation: Centre for Biomolecular Sciences, University of St Andrews, St Andrews, United Kingdom

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  • Patricia C. Babbitt mail

    babbitt@cgl.ucsf.edu

    Affiliations: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America

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  • Published: March 12, 2010
  • DOI: 10.1371/journal.pcbi.1000700

About the Authors

Daniel E. Almonacid, Patricia C. Babbitt
Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America
Daniel E. Almonacid, Patricia C. Babbitt
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Daniel E. Almonacid, Patricia C. Babbitt
California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America
Emmanuel R. Yera
Biological and Medical Informatics Graduate Program, University of California San Francisco, San Francisco, California, United States of America
John B. O. Mitchell
Centre for Biomolecular Sciences, University of St Andrews, St Andrews, United Kingdom

Corresponding Author

Email: babbitt@cgl.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DEA JBOM PCB. Performed the experiments: DEA ERY. Analyzed the data: DEA. Wrote the paper: DEA ERY JBOM PCB.