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Research Article

Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement

  • Laurence Calzone mail,

    Laurence.Calzone@curie.fr

    Affiliations: Institut Curie, Paris, France, Ecole des Mines ParisTech, Paris, France, INSERM U900, Paris, France

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  • Laurent Tournier,

    Affiliations: Institut Curie, Paris, France, Ecole des Mines ParisTech, Paris, France, INSERM U900, Paris, France

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  • Simon Fourquet,

    Affiliations: Institut Curie, Paris, France, Ecole des Mines ParisTech, Paris, France, INSERM U900, Paris, France

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  • Denis Thieffry,

    Affiliations: TAGC – INSERM U928 & Université de la Méditerranée, Marseille, France, CONTRAINTES Project, INRIA Paris-Rocquencourt, France

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  • Boris Zhivotovsky,

    Affiliation: Karolinska Institutet, Stockholm, Sweden

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  • Emmanuel Barillot ,

    Affiliations: Institut Curie, Paris, France, Ecole des Mines ParisTech, Paris, France, INSERM U900, Paris, France

    These authors are joint senior authors on this work.

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  • Andrei Zinovyev

    Affiliations: Institut Curie, Paris, France, Ecole des Mines ParisTech, Paris, France, INSERM U900, Paris, France

    These authors are joint senior authors on this work.

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  • Published: March 05, 2010
  • DOI: 10.1371/journal.pcbi.1000702

About the Authors

Laurence Calzone, Laurent Tournier, Simon Fourquet, Emmanuel Barillot, Andrei Zinovyev
Institut Curie, Paris, France
Laurence Calzone, Laurent Tournier, Simon Fourquet, Emmanuel Barillot, Andrei Zinovyev
Ecole des Mines ParisTech, Paris, France
Laurence Calzone, Laurent Tournier, Simon Fourquet, Emmanuel Barillot, Andrei Zinovyev
INSERM U900, Paris, France
Denis Thieffry
TAGC – INSERM U928 & Université de la Méditerranée, Marseille, France
Denis Thieffry
CONTRAINTES Project, INRIA Paris-Rocquencourt, France
Boris Zhivotovsky
Karolinska Institutet, Stockholm, Sweden

Corresponding Author

Email: Laurence.Calzone@curie.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LC LT SF DT BZ EB AZ. Performed the experiments: LC LT SF DT BZ EB AZ. Analyzed the data: LC LT SF DT BZ EB AZ. Contributed reagents/materials/analysis tools: LC LT SF DT BZ EB AZ. Wrote the paper: LC LT SF DT BZ EB AZ. Created, validated and proposed predictions of the model: LC LT SF DT BZ AZ. Coordinated the project: EB AZ. Edited and finalized the paper: LC. Developed the methodology for cell fate probability prediction: LT. Provided GINsim assistance: DT.