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Research Article

Modeling Co-Expression across Species for Complex Traits: Insights to the Difference of Human and Mouse Embryonic Stem Cells

  • Jun Cai,

    Affiliation: Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America

    Current address: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

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  • Dan Xie,

    Affiliation: Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America

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  • Zhewen Fan,

    Affiliations: Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America, Department of Statistics, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America

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  • Hiram Chipperfield,

    Affiliation: Institute of Medical Biology, Singapore

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  • John Marden,

    Affiliation: Department of Statistics, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America

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  • Wing H. Wong,

    Affiliations: Department of Statistics, Stanford University, Stanford, California, United States of America, Department of Health Research and Policy, Stanford University, Stanford, California, United States of America

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  • Sheng Zhong mail

    szhong@illinois.edu

    Affiliations: Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America, Department of Statistics, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America, Institute of Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America

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  • Published: March 12, 2010
  • DOI: 10.1371/journal.pcbi.1000707

About the Authors

Jun Cai, Dan Xie, Zhewen Fan, Sheng Zhong
Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
Zhewen Fan, John Marden, Sheng Zhong
Department of Statistics, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
Wing H. Wong
Department of Statistics, Stanford University, Stanford, California, United States of America
Wing H. Wong
Department of Health Research and Policy, Stanford University, Stanford, California, United States of America
Hiram Chipperfield
Institute of Medical Biology, Singapore
Sheng Zhong
Institute of Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America

Corresponding Author

Email: szhong@illinois.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SZ. Performed the experiments: HC WHW. Analyzed the data: JC DX ZF SZ. Contributed reagents/materials/analysis tools: JC DX ZF JM WHW SZ. Wrote the paper: SZ.