About the Authors
- Younghee Lee
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Contributed equally to this work with: Younghee Lee, Xinan Yang, Yong Huang, Hanli Fan
Affiliation Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
- Xinan Yang
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Contributed equally to this work with: Younghee Lee, Xinan Yang, Yong Huang, Hanli Fan
Affiliation Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
- Yong Huang
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Contributed equally to this work with: Younghee Lee, Xinan Yang, Yong Huang, Hanli Fan
Affiliation Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
- Hanli Fan
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Contributed equally to this work with: Younghee Lee, Xinan Yang, Yong Huang, Hanli Fan
Affiliation Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America
- Qingbei Zhang
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Affiliation Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America
- Youngfei Wu
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Affiliation Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America
- Jianrong Li
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Affiliation Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
- Rifat Hasina
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Affiliation Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America
- Chao Cheng
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Affiliation Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Mark W. Lingen
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Affiliations Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America, Department of Cellular and Radiation Oncology, The University of Chicago, Chicago, Illinois, United States of America
- Mark B. Gerstein
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Affiliation Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Ralph R. Weichselbaum
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Affiliations Department of Cellular and Radiation Oncology, The University of Chicago, Chicago, Illinois, United States of America, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois, United States of America
- H. Rosie Xing
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* E-mail: hxing@bsd.uchicago.edu (HRX); yLussier@medicine.bsd.uchicago.edu (YAL)
¶These authors are joint senior authors on this work.
Affiliations Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America, Department of Cellular and Radiation Oncology, The University of Chicago, Chicago, Illinois, United States of America, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois, United States of America
- Yves A. Lussier
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* E-mail: hxing@bsd.uchicago.edu (HRX); yLussier@medicine.bsd.uchicago.edu (YAL)
¶These authors are joint senior authors on this work.
Affiliations Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois, United States of America, Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: YL XY YH HF QZ YW JL HRX YAL. Performed the experiments: YL XY YH HF QZ YW JL. Analyzed the data: YL XY YH HF QZ YW JL HRX YAL. Contributed reagents/materials/analysis tools: YL XY JL RH CC MWL MBG RRW HRX YAL. Wrote the paper: YL XY YH HF QZ YW JL CC RRW HRX YAL. Conceived computational methods and interpreted the results: YL XY YH CC MB YAL. Conducted all qPCR validations, cell adhesion and migration assays: HF. Treated JSQ and SQ38 cells with control and miR-204 mimics for in vitro and in vivo experiments and conducted proliferation and invasion assays: YW. Performed in vivo lung metastasis experiments and lung metastatic colony quantification: QZ. Obtained, classified and micro-dissected head and neck tumor samples: RH ML. Provided all HNSCC cell lines: RRW. Conceived biological experiemnts and interpreted the results: HRX. Supervised the overall research: HRX. Supervised the research: YAL.