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Research Article

A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions

  • Chuan-Yun Li,

    Affiliation: Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China

    X
  • Yong Zhang,

    Affiliation: Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America

    X
  • Zhanbo Wang,

    Affiliation: Department of Pathology, Chinese PLA General Hospital, Beijing, China

    X
  • Yan Zhang,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Chunmei Cao,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Ping-Wu Zhang,

    Affiliation: Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America

    X
  • Shu-Juan Lu,

    Affiliation: Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China

    X
  • Xiao-Mo Li,

    Affiliation: Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China

    X
  • Quan Yu,

    Affiliation: Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China

    X
  • Xiaofeng Zheng,

    Affiliation: Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China

    X
  • Quan Du,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • George R. Uhl,

    Affiliation: Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America

    X
  • Qing-Rong Liu mail,

    qrliu1@verizon.net (Q-RL); weilp@mail.cbi.pku.edu.cn (LW)

    Affiliation: Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland, United States of America

    X
  • Liping Wei mail

    qrliu1@verizon.net (Q-RL); weilp@mail.cbi.pku.edu.cn (LW)

    Affiliation: Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China

    X
  • Published: March 26, 2010
  • DOI: 10.1371/journal.pcbi.1000734

About the Authors

Chuan-Yun Li, Shu-Juan Lu, Xiao-Mo Li, Liping Wei
Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China
Yong Zhang
Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America
Zhanbo Wang
Department of Pathology, Chinese PLA General Hospital, Beijing, China
Yan Zhang, Chunmei Cao, Quan Du
Institute of Molecular Medicine, Peking University, Beijing, China
Ping-Wu Zhang, George R. Uhl
Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America
Quan Yu, Xiaofeng Zheng
Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China
Qing-Rong Liu
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Chuan-Yun Li, George R Uhl, Qing-Rong Liu, Liping Wei. Performed the experiments: Chuan-Yun Li, Zhanbo Wang, Yan Zhang, Chunmei Cao, Ping-Wu Zhang, Shu-Juan Lu, Xiao-Mo Li, Quan Yu, Xiaofeng Zheng, Quan Du. Analyzed the data: Chuan-Yun Li, Yong Zhang. Wrote the paper: Chuan-Yun Li, Yong Zhang, Qing-Rong Liu, Liping Wei. Performed most of the experiments: Chuan-Yun Li. Conceived the idea: Chuan-Yun Li, Liping Wei.