Advertisement
Research Article

New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach

  • Enrico Petretto equal contributor,

    equal contributor Contributed equally to this work with: Enrico Petretto, Leonardo Bottolo

    Affiliations: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom, Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom

    X
  • Leonardo Bottolo equal contributor,

    equal contributor Contributed equally to this work with: Enrico Petretto, Leonardo Bottolo

    Affiliations: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom, Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom

    X
  • Sarah R. Langley,

    Affiliation: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom

    X
  • Matthias Heinig,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

    X
  • Chris McDermott-Roe,

    Affiliation: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom

    X
  • Rizwan Sarwar,

    Affiliation: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom

    X
  • Michal Pravenec,

    Affiliations: Institute of Physiology, Czech Academy of Sciences and Centre for Applied Genomics, Prague, Czech Republic, Charles University in Prague, Institute of Biology and Medical Genetics of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic

    X
  • Norbert Hübner,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

    X
  • Timothy J. Aitman,

    Affiliations: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom, Section of Molecular Genetics and Rheumatology, Division and Faculty of Medicine, Imperial College, London, United Kingdom

    X
  • Stuart A. Cook,

    Affiliations: Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom, National Heart and Lung Institute, Imperial College, London, United Kingdom

    X
  • Sylvia Richardson mail

    sylvia.richardson@imperial.ac.uk

    Affiliation: Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom

    X
  • Published: April 08, 2010
  • DOI: 10.1371/journal.pcbi.1000737

About the Authors

Enrico Petretto, Leonardo Bottolo, Sarah R. Langley, Chris McDermott-Roe, Rizwan Sarwar, Timothy J. Aitman, Stuart A. Cook
Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom
Enrico Petretto, Leonardo Bottolo, Sylvia Richardson
Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom
Matthias Heinig, Norbert Hübner
Max-Delbrück Center for Molecular Medicine, Berlin, Germany
Michal Pravenec
Institute of Physiology, Czech Academy of Sciences and Centre for Applied Genomics, Prague, Czech Republic
Michal Pravenec
Charles University in Prague, Institute of Biology and Medical Genetics of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
Timothy J. Aitman
Section of Molecular Genetics and Rheumatology, Division and Faculty of Medicine, Imperial College, London, United Kingdom
Stuart A. Cook
National Heart and Lung Institute, Imperial College, London, United Kingdom

Corresponding Author

Email: sylvia.richardson@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed the study: EP LB. Developed the code for the SBR and SBMR analyses: LB. Performed all statistical analyses: EP LB SRL. Performed all PCR based experiments: CMR RS SAC. Contributed reagents and materials for the study: MH MP NH TJA SAC. Wrote the paper: EP LB SR.