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Research Article

Asymmetric Switching in a Homodimeric ABC Transporter: A Simulation Study

  • Jussi Aittoniemi,

    Affiliations: Department of Biochemistry, University of Oxford, Oxford, United Kingdom, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Heidi de Wet,

    Affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Frances M. Ashcroft,

    Affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Mark S. P. Sansom mail

    mark.sansom@bioch.ox.ac.uk

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Published: April 29, 2010
  • DOI: 10.1371/journal.pcbi.1000762

About the Authors

Jussi Aittoniemi, Mark S. P. Sansom
Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Jussi Aittoniemi, Heidi de Wet, Frances M. Ashcroft
Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: mark.sansom@bioch.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JA MSPS. Performed the experiments: JA. Analyzed the data: JA. Wrote the paper: JA HdW FMA MSPS. Contributed to the writing of the paper and discussions of the analysis of the simulations: FMA.