A New Approach for Determining Phase Response Curves Reveals that Purkinje Cells Can Act as Perfect Integrators

Elena Phoka; Hermann Cuntz; Arnd Roth; Michael Häusser

doi:10.1371/journal.pcbi.1000768

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Open Access

Peer-reviewed

Research Article

A New Approach for Determining Phase Response Curves Reveals that Purkinje Cells Can Act as Perfect Integrators

Elena Phoka ,

Contributed equally to this work with: Elena Phoka, Hermann Cuntz

* E-mail: e.phoka07@imperial.ac.uk

Affiliations Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom, Department of Bioengineering, Imperial College London, London, United Kingdom
⨯
Hermann Cuntz ,

Contributed equally to this work with: Elena Phoka, Hermann Cuntz

Affiliation Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
⨯
Arnd Roth,

Affiliation Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
⨯
Michael Häusser

Affiliation Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
⨯

A New Approach for Determining Phase Response Curves Reveals that Purkinje Cells Can Act as Perfect Integrators

Elena Phoka,
Hermann Cuntz,
Arnd Roth,
Michael Häusser

Published: April 29, 2010
https://doi.org/10.1371/journal.pcbi.1000768

About the Authors

Elena Phoka

Contributed equally to this work with: Elena Phoka, Hermann Cuntz

* E-mail: e.phoka07@imperial.ac.uk

Affiliations Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom, Department of Bioengineering, Imperial College London, London, United Kingdom

Hermann Cuntz

Contributed equally to this work with: Elena Phoka, Hermann Cuntz

Affiliation Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom

Arnd Roth

Affiliation Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom

Michael Häusser

Affiliation Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EP HC AR MH. Performed the experiments: EP. Analyzed the data: EP HC. Contributed reagents/materials/analysis tools: EP HC. Wrote the paper: EP HC AR MH. Performed the modeling: EP HC AR.

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Purkinje cells
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Neurons
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Action potentials
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Integrators
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Phase determination
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Solid-phase extraction
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Behavior
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Membrane potential
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