Advertisement
Research Article

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences

  • Vinal V. Lakhani,

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Feng Ding,

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Nikolay V. Dokholyan mail

    dokh@med.unc.edu

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Published: April 29, 2010
  • DOI: 10.1371/journal.pcbi.1000772

About the Authors

Vinal V. Lakhani, Feng Ding, Nikolay V. Dokholyan
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: dokh@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FD NVD. Performed the experiments: VVL FD NVD. Analyzed the data: VVL FD NVD. Wrote the paper: VVL FD NVD.