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Research Article

Mathematical Modelling of DNA Replication Reveals a Trade-off between Coherence of Origin Activation and Robustness against Rereplication

  • Anneke Brümmer,

    Affiliations: Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany, BioQuant Center, Heidelberg, Germany

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  • Carlos Salazar,

    Affiliations: Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany, BioQuant Center, Heidelberg, Germany

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  • Vittoria Zinzalla,

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Lilia Alberghina mail,

    lilia.alberghina@unimib.it (LA); t.hoefer@dkfz-heidelberg.de (TH)

    Affiliation: Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Milan, Italy

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  • Thomas Höfer mail

    lilia.alberghina@unimib.it (LA); t.hoefer@dkfz-heidelberg.de (TH)

    Affiliations: Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany, BioQuant Center, Heidelberg, Germany

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  • Published: May 13, 2010
  • DOI: 10.1371/journal.pcbi.1000783

About the Authors

Anneke Brümmer, Carlos Salazar, Thomas Höfer
Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany
Lilia Alberghina
Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Milan, Italy
Anneke Brümmer, Carlos Salazar, Thomas Höfer
BioQuant Center, Heidelberg, Germany
Vittoria Zinzalla
Biozentrum, University of Basel, Basel, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB CS VZ LA TH. Performed the experiments: AB. Analyzed the data: AB CS LA TH. Wrote the paper: AB CS LA TH.