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Research Article

Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor Exploits Competition between L-Arginine Ligands and Resident Arginine Residues

  • Rebecca Strawn equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Strawn, Milan Melichercik

    Affiliation: Chemistry Department, Princeton University, Princeton, New Jersey, United States of America

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  • Milan Melichercik equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Strawn, Milan Melichercik

    Affiliation: Department of Structure and Function of Proteins, Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, and Institute of Physical Biology, University of South Bohemia, Nove Hrady, Czech Republic

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  • Michael Green,

    Affiliation: Biology Department, The College of New Jersey, Ewing, New Jersey, United States of America

    Current address: Mount Sinai School of Medicine, New York, New York, United States of America

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  • Thomas Stockner,

    Affiliation: Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria

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  • Jannette Carey mail,

    jcarey@princeton.edu (JC); ettrich@nh.usbe.cas.cz (RE)

    Affiliation: Chemistry Department, Princeton University, Princeton, New Jersey, United States of America

    X
  • Rüdiger Ettrich mail

    jcarey@princeton.edu (JC); ettrich@nh.usbe.cas.cz (RE)

    Affiliation: Department of Structure and Function of Proteins, Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, and Institute of Physical Biology, University of South Bohemia, Nove Hrady, Czech Republic

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  • Published: June 03, 2010
  • DOI: 10.1371/journal.pcbi.1000801

About the Authors

Rebecca Strawn, Jannette Carey
Chemistry Department, Princeton University, Princeton, New Jersey, United States of America
Milan Melichercik, Rüdiger Ettrich
Department of Structure and Function of Proteins, Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, and Institute of Physical Biology, University of South Bohemia, Nove Hrady, Czech Republic
Michael Green
Biology Department, The College of New Jersey, Ewing, New Jersey, United States of America
Thomas Stockner
Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JC RE. Performed the experiments: RS MM MG. Analyzed the data: RS MM TS JC RE. Wrote the paper: RS MM TS JC RE.