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Research Article

Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations

  • Robert Schulz equal contributor,

    equal contributor Contributed equally to this work with: Robert Schulz, Attilio V. Vargiu

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Attilio V. Vargiu equal contributor mail,

    equal contributor Contributed equally to this work with: Robert Schulz, Attilio V. Vargiu

    vargiu@dsf.unica.it

    Affiliation: Istituto Officina dei Materiali del CNR, UOS SLACS and Dipartimento di Fisica, Universita' degli Studi di Cagliari, Monserrato, Italy

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  • Francesca Collu,

    Affiliation: Istituto Officina dei Materiali del CNR, UOS SLACS and Dipartimento di Fisica, Universita' degli Studi di Cagliari, Monserrato, Italy

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  • Ulrich Kleinekathöfer,

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Paolo Ruggerone

    Affiliation: Istituto Officina dei Materiali del CNR, UOS SLACS and Dipartimento di Fisica, Universita' degli Studi di Cagliari, Monserrato, Italy

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  • Published: June 10, 2010
  • DOI: 10.1371/journal.pcbi.1000806

About the Authors

Robert Schulz, Ulrich Kleinekathöfer
School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
Attilio V. Vargiu, Francesca Collu, Paolo Ruggerone
Istituto Officina dei Materiali del CNR, UOS SLACS and Dipartimento di Fisica, Universita' degli Studi di Cagliari, Monserrato, Italy

Corresponding Author

Email: vargiu@dsf.unica.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS AVV UK PR. Performed the experiments: RS AVV FC. Analyzed the data: RS AVV UK PR. Contributed reagents/materials/analysis tools: RS AVV. Wrote the paper: RS AVV UK PR. Contributed materials: FC.