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Research Article

Fast- or Slow-inactivated State Preference of Na+ Channel Inhibitors: A Simulation and Experimental Study

  • Robert Karoly,

    Affiliation: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

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  • Nora Lenkey,

    Affiliation: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

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  • Andras O. Juhasz,

    Affiliation: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

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  • E. Sylvester Vizi,

    Affiliation: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

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  • Arpad Mike mail

    mike@koki.hu

    Affiliation: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

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  • Published: June 17, 2010
  • DOI: 10.1371/journal.pcbi.1000818

About the Authors

Robert Karoly, Nora Lenkey, Andras O. Juhasz, E. Sylvester Vizi, Arpad Mike
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

Corresponding Author

Email: mike@koki.hu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RK ESV AM. Performed the experiments: RK NL. Analyzed the data: RK NL AOJ AM. Contributed reagents/materials/analysis tools: AOJ. Wrote the paper: RK AM.