Plato's Cave Algorithm: Inferring Functional Signaling Networks from Early Gene Expression Shadows

Yishai Shimoni; Marc Y. Fink; Soon-gang Choi; Stuart C. Sealfon

doi:10.1371/journal.pcbi.1000828

Loading metrics

Open Access

Peer-reviewed

Research Article

Plato's Cave Algorithm: Inferring Functional Signaling Networks from Early Gene Expression Shadows

Yishai Shimoni ,

Contributed equally to this work with: Yishai Shimoni, Marc Y. Fink

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Marc Y. Fink ,

Contributed equally to this work with: Yishai Shimoni, Marc Y. Fink

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Soon-gang Choi,

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Stuart C. Sealfon

* E-mail: stuart.sealfon@mssm.edu

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯

Plato's Cave Algorithm: Inferring Functional Signaling Networks from Early Gene Expression Shadows

Yishai Shimoni,
Marc Y. Fink,
Soon-gang Choi,
Stuart C. Sealfon

Published: June 24, 2010
https://doi.org/10.1371/journal.pcbi.1000828

About the Authors

Yishai Shimoni

Contributed equally to this work with: Yishai Shimoni, Marc Y. Fink

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Marc Y. Fink

Contributed equally to this work with: Yishai Shimoni, Marc Y. Fink

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Soon-gang Choi

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Stuart C. Sealfon

* E-mail: stuart.sealfon@mssm.edu

Affiliation Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YS MYF SCS. Performed the experiments: MYF SGC. Analyzed the data: YS MYF. Contributed reagents/materials/analysis tools: YS MYF. Wrote the paper: YS MYF SCS.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Signal processing
Is the Subject Area "Signal processing" applicable to this article?

Thanks for your feedback.
Drug interactions
Is the Subject Area "Drug interactions" applicable to this article?

Thanks for your feedback.
Signaling networks
Is the Subject Area "Signaling networks" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Genetic engineering
Is the Subject Area "Genetic engineering" applicable to this article?

Thanks for your feedback.
Interaction networks
Is the Subject Area "Interaction networks" applicable to this article?

Thanks for your feedback.
Algorithms
Is the Subject Area "Algorithms" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.