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Research Article

The Energy Landscape, Folding Pathways and the Kinetics of a Knotted Protein

  • Michael C. Prentiss mail,

    mcprentiss@gmail.com

    Affiliations: Department of Chemistry, Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America, International Institute for Complex Adaptive Matter, University of California Davis, Davis, California, United States of America

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  • David J. Wales,

    Affiliation: University Chemical Laboratories, Cambridge, United Kingdom

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  • Peter G. Wolynes

    Affiliations: Department of Chemistry, Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America, International Institute for Complex Adaptive Matter, University of California Davis, Davis, California, United States of America

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.pcbi.1000835

About the Authors

Michael C. Prentiss, Peter G. Wolynes
Department of Chemistry, Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America
Michael C. Prentiss, Peter G. Wolynes
International Institute for Complex Adaptive Matter, University of California Davis, Davis, California, United States of America
David J. Wales
University Chemical Laboratories, Cambridge, United Kingdom

Corresponding Author

Email: mcprentiss@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MCP DJW PGW. Performed the experiments: MCP DJW. Analyzed the data: MCP DJW PGW. Contributed reagents/materials/analysis tools: MCP DJW PGW. Wrote the paper: MCP DJW PGW.