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Research Article

The Construction and Use of Log-Odds Substitution Scores for Multiple Sequence Alignment

  • Stephen F. Altschul mail,

    altschul@ncbi.nlm.nih.gov

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • John C. Wootton,

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Elena Zaslavsky,

    Affiliation: Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Yi-Kuo Yu

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: July 15, 2010
  • DOI: 10.1371/journal.pcbi.1000852

About the Authors

Stephen F. Altschul, John C. Wootton, Yi-Kuo Yu
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
Elena Zaslavsky
Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: altschul@ncbi.nlm.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SFA JCW EZ YKY. Performed the experiments: SFA JCW YKY. Analyzed the data: SFA JCW YKY. Wrote the paper: SFA JCW EZ YKY. Developed mathematical theory: SFA YKY.