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Research Article

Intrinsically Disordered Regions May Lower the Hydration Free Energy in Proteins: A Case Study of Nudix Hydrolase in the Bacterium Deinococcus radiodurans

  • Omar Awile,

    Affiliations: Mediterranean Institute for Life Sciences, Split, Croatia, Institute of Theoretical Computer Science and Swiss Institute of Bioinformatics, Zürich, Switzerland

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  • Anita Krisko,

    Affiliation: Faculte de Medecine Paris Descartes, INSERM U1001, Paris, France

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  • Ivo F. Sbalzarini,

    Affiliations: Mediterranean Institute for Life Sciences, Split, Croatia, Institute of Theoretical Computer Science and Swiss Institute of Bioinformatics, Zürich, Switzerland

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  • Bojan Zagrovic mail

    bojan.zagrovic@univie.ac.at

    Affiliations: Mediterranean Institute for Life Sciences, Split, Croatia, Department of Physics, University of Split, Split, Croatia, University of Vienna, Department of Structural & Computational Biology, Max F. Perutz Laboratories, Vienna, Austria

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  • Published: July 15, 2010
  • DOI: 10.1371/journal.pcbi.1000854

About the Authors

Omar Awile, Ivo F. Sbalzarini, Bojan Zagrovic
Mediterranean Institute for Life Sciences, Split, Croatia
Omar Awile, Ivo F. Sbalzarini
Institute of Theoretical Computer Science and Swiss Institute of Bioinformatics, Zürich, Switzerland
Anita Krisko
Faculte de Medecine Paris Descartes, INSERM U1001, Paris, France
Bojan Zagrovic
Department of Physics, University of Split, Split, Croatia
Bojan Zagrovic
University of Vienna, Department of Structural & Computational Biology, Max F. Perutz Laboratories, Vienna, Austria

Corresponding Author

Email: bojan.zagrovic@univie.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OA AK IFS BZ. Performed the experiments: OA AK. Analyzed the data: OA AK. Contributed reagents/materials/analysis tools: OA BZ. Wrote the paper: OA IFS BZ.