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Research Article

Sampling the Solution Space in Genome-Scale Metabolic Networks Reveals Transcriptional Regulation in Key Enzymes

  • Sergio Bordel,

    Affiliation: Systems Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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  • Rasmus Agren,

    Affiliation: Systems Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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  • Jens Nielsen mail

    nielsenj@chalmers.se

    Affiliation: Systems Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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  • Published: July 15, 2010
  • DOI: 10.1371/journal.pcbi.1000859

About the Authors

Sergio Bordel, Rasmus Agren, Jens Nielsen
Systems Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

Corresponding Author

Email: nielsenj@chalmers.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SB JN. Analyzed the data: SB RA. Wrote the paper: SB.