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Research Article

VASP: A Volumetric Analysis of Surface Properties Yields Insights into Protein-Ligand Binding Specificity

  • Brian Y. Chen,

    Affiliations: Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America, Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America

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  • Barry Honig mail

    bh6@columbia.edu

    Affiliations: Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America, Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America

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  • Published: August 12, 2010
  • DOI: 10.1371/journal.pcbi.1000881

About the Authors

Brian Y. Chen, Barry Honig
Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America
Brian Y. Chen, Barry Honig
Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America

Corresponding Author

Email: bh6@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BYC. Performed the experiments: BYC. Analyzed the data: BYC BH. Contributed reagents/materials/analysis tools: BYC BH. Wrote the paper: BYC BH.