Advertisement
Research Article

Linking Changes in Epithelial Morphogenesis to Cancer Mutations Using Computational Modeling

  • Katarzyna A. Rejniak mail,

    Kasia.Rejniak@moffitt.org

    Affiliations: Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America, Department of Oncologic Sciences, University of South Florida College of Medicine, Tampa, Florida, United States of America

    X
  • Shizhen E. Wang,

    Affiliation: Division of Tumor Cell Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America

    X
  • Nicole S. Bryce,

    Affiliation: Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    Current address: School of Chemistry, University of Sydney, Sydney, Australia

    X
  • Hang Chang,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Bahram Parvin,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Jerome Jourquin,

    Affiliation: Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Lourdes Estrada,

    Affiliation: Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Joe W. Gray,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Carlos L. Arteaga,

    Affiliation: Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Alissa M. Weaver,

    Affiliation: Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Vito Quaranta equal contributor,

    equal contributor Contributed equally to this work with: Vito Quaranta, Alexander R. A. Anderson

    Affiliation: Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Alexander R. A. Anderson equal contributor

    equal contributor Contributed equally to this work with: Vito Quaranta, Alexander R. A. Anderson

    Affiliation: Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

    X
  • Published: August 26, 2010
  • DOI: 10.1371/journal.pcbi.1000900

About the Authors

Katarzyna A. Rejniak, Alexander R. A. Anderson
Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America
Katarzyna A. Rejniak
Department of Oncologic Sciences, University of South Florida College of Medicine, Tampa, Florida, United States of America
Shizhen E. Wang
Division of Tumor Cell Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
Nicole S. Bryce, Jerome Jourquin, Lourdes Estrada, Carlos L. Arteaga, Alissa M. Weaver, Vito Quaranta
Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Hang Chang, Bahram Parvin, Joe W. Gray
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Corresponding Author

Email: Kasia.Rejniak@moffitt.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SEW NSB LE CLA AMW VQ. Performed the experiments: SEW NSB. Analyzed the data: KAR HC BP JJ. Contributed reagents/materials/analysis tools: BP JWG CLA AMW VQ. Wrote the paper: KAR VQ ARAA. Conceived and designed the computational model: KAR ARAA. Performed computational simulations: KAR.