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Research Article

Rescuing Loading Induced Bone Formation at Senescence

  • Sundar Srinivasan mail,

    sundars@u.washington.edu

    Affiliation: Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America

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  • Brandon J. Ausk,

    Affiliation: Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America

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  • Jitendra Prasad,

    Affiliation: Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America

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  • Dewayne Threet,

    Affiliation: Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America

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  • Steven D. Bain,

    Affiliation: Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America

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  • Thomas S. Richardson,

    Affiliation: Department of Statistics, University of Washington, Seattle, Washington, United States of America

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  • Ted S. Gross

    Affiliation: Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America

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  • Published: September 09, 2010
  • DOI: 10.1371/journal.pcbi.1000924

About the Authors

Sundar Srinivasan, Brandon J. Ausk, Jitendra Prasad, Dewayne Threet, Steven D. Bain, Ted S. Gross
Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America
Thomas S. Richardson
Department of Statistics, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: sundars@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS SDB TSR TSG. Performed the experiments: SS BJA JP DT. Analyzed the data: SS BJA JP DT. Contributed reagents/materials/analysis tools: SS BJA JP SDB TSR. Wrote the paper: SS TSR TSG.