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Research Article

Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs

  • Ying Liu,

    Affiliation: Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Lila M. Gierasch,

    Affiliation: Department of Biochemistry and Molecular Biology, and Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

    X
  • Ivet Bahar mail

    bahar@pitt.edu

    Affiliation: Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: September 16, 2010
  • DOI: 10.1371/journal.pcbi.1000931

About the Authors

Ying Liu, Ivet Bahar
Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Lila M. Gierasch
Department of Biochemistry and Molecular Biology, and Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

Corresponding Author

Email: bahar@pitt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YL IB. Performed the experiments: YL. Analyzed the data: YL LMG IB. Contributed reagents/materials/analysis tools: YL IB. Wrote the paper: YL LMG IB.