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Research Article

Selection upon Genome Architecture: Conservation of Functional Neighborhoods with Changing Genes

  • Fátima Al-Shahrour,

    Affiliation: Department of Bioinformatics and Genomics, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain

    Current address: Broad Institute, Cambridge, Massachusetts, United States of America

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  • Pablo Minguez,

    Affiliation: Department of Bioinformatics and Genomics, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain

    Current address: Structural and Computational Biology Unit, EMBL Heidelberg, Heidelberg, Germany

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  • Tomás Marqués-Bonet,

    Affiliations: Institut de Biologia Evolutiva, Universitat Pompeu Fabra (UPF) and Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

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  • Elodie Gazave,

    Affiliation: Institut de Biologia Evolutiva, Universitat Pompeu Fabra (UPF) and Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain

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  • Arcadi Navarro,

    Affiliations: Institut de Biologia Evolutiva, Universitat Pompeu Fabra (UPF) and Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain, Population Genomics Node (National Institute for Bioinformatics, INB), Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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  • Joaquín Dopazo mail

    jdopazo@cipf.es

    Affiliations: Department of Bioinformatics and Genomics, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain, CIBER de Enfermedades Raras (CIBERER), Valencia, Spain, Functional Genomics Node (National Institute for Bioinformatics, INB), CIPF, Valencia, Spain

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  • Published: October 07, 2010
  • DOI: 10.1371/journal.pcbi.1000953

About the Authors

Fátima Al-Shahrour, Pablo Minguez, Joaquín Dopazo
Department of Bioinformatics and Genomics, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
Tomás Marqués-Bonet, Elodie Gazave, Arcadi Navarro
Institut de Biologia Evolutiva, Universitat Pompeu Fabra (UPF) and Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain
Tomás Marqués-Bonet
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Tomás Marqués-Bonet
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America
Arcadi Navarro
Population Genomics Node (National Institute for Bioinformatics, INB), Barcelona, Spain
Arcadi Navarro
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
Joaquín Dopazo
CIBER de Enfermedades Raras (CIBERER), Valencia, Spain
Joaquín Dopazo
Functional Genomics Node (National Institute for Bioinformatics, INB), CIPF, Valencia, Spain

Corresponding Author

Email: jdopazo@cipf.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JD. Analyzed the data: FAS PM TMB EG AN. Wrote the paper: AN JD.