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Research Article

Evolution of a Signaling Nexus Constrained by Protein Interfaces and Conformational States

  • Brenda R. S. Temple mail,

    btemple@med.unc.edu

    Affiliations: R. L. Juliano Structural Bioinformatics Core Facility, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Corbin D. Jones,

    Affiliations: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Alan M. Jones

    Affiliations: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Published: October 14, 2010
  • DOI: 10.1371/journal.pcbi.1000962

About the Authors

Brenda R. S. Temple
R. L. Juliano Structural Bioinformatics Core Facility, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Brenda R. S. Temple
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Corbin D. Jones, Alan M. Jones
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Corbin D. Jones
Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Alan M. Jones
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: btemple@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BRST AMJ. Performed the experiments: BRST. Analyzed the data: BRST CDJ AMJ. Contributed reagents/materials/analysis tools: BRST CDJ AMJ. Wrote the paper: BRST CDJ AMJ.