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Research Article

Numerical Analysis of Ca2+ Signaling in Rat Ventricular Myocytes with Realistic Transverse-Axial Tubular Geometry and Inhibited Sarcoplasmic Reticulum

  • Yuhui Cheng,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • Zeyun Yu,

    Affiliation: Department of Computer Science, University of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Masahiko Hoshijima,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Michael J. Holst,

    Affiliation: Department of Mathematics, University of California San Diego, La Jolla, California, United States of America

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  • Andrew D. McCulloch,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • J. Andrew McCammon,

    Affiliations: Department of Chemistry and Biochemistry, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

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  • Anushka P. Michailova mail

    amihaylo@bioeng.ucsd.edu

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • Published: October 28, 2010
  • DOI: 10.1371/journal.pcbi.1000972

About the Authors

Yuhui Cheng, Andrew D. McCulloch, Anushka P. Michailova
Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America
Zeyun Yu
Department of Computer Science, University of Wisconsin, Milwaukee, Wisconsin, United States of America
Masahiko Hoshijima
Department of Medicine, University of California San Diego, La Jolla, California, United States of America
Michael J. Holst
Department of Mathematics, University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
Department of Chemistry and Biochemistry, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: amihaylo@bioeng.ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APM. Performed the experiments: YC. Analyzed the data: YC ADM APM. Contributed reagents/materials/analysis tools: YC ZY MH MJH JAM APM. Wrote the paper: YC JAM APM.