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Research Article

The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications

  • Sarah L. Kinnings,

    Affiliations: Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom, San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, United States of America

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  • Li Xie,

    Affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

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  • Kingston H. Fung,

    Affiliation: Bioinformatics Program, University of California, San Diego, La Jolla, California, United States of America

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  • Richard M. Jackson,

    Affiliation: Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom

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  • Lei Xie mail,

    lxie@ucsd.edu (LX); pbourne@ucsd.edu (PEB)

    Affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

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  • Philip E. Bourne mail

    lxie@ucsd.edu (LX); pbourne@ucsd.edu (PEB)

    Affiliations: San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.pcbi.1000976

About the Authors

Sarah L. Kinnings, Richard M. Jackson
Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
Sarah L. Kinnings, Philip E. Bourne
San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, United States of America
Li Xie, Lei Xie, Philip E. Bourne
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America
Kingston H. Fung
Bioinformatics Program, University of California, San Diego, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Lei Xie. Performed the experiments: Sarah L. Kinnings, Li Xie, Kingston H. Fung, Lei Xie. Analyzed the data: Sarah L. Kinnings, Li Xie, Lei Xie. Contributed reagents/materials/analysis tools: Lei Xie. Wrote the paper: Sarah L. Kinnings, Li Xie, Lei Xie, Philip E. Bourne. Reviewed the paper: Richard M. Jackson.