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Research Article

Networks of High Mutual Information Define the Structural Proximity of Catalytic Sites: Implications for Catalytic Residue Identification

  • Cristina Marino Buslje equal contributor mail,

    equal contributor Contributed equally to this work with: Cristina Marino Buslje, Elin Teppa

    cmb@leloir.org.ar

    Affiliation: Fundación Instituto Leloir, Buenos Aires, Argentina

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  • Elin Teppa equal contributor,

    equal contributor Contributed equally to this work with: Cristina Marino Buslje, Elin Teppa

    Affiliation: Fundación Instituto Leloir, Buenos Aires, Argentina

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  • Tomas Di Doménico,

    Affiliation: Institute of Biochemistry and Biophysics (IQUIFIB), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

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  • José María Delfino,

    Affiliation: Institute of Biochemistry and Biophysics (IQUIFIB), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

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  • Morten Nielsen

    Affiliation: Center for Biological Sequence Analysis, Department of Systems Biology, The Technical University of Denmark, Lyngby, Denmark

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.pcbi.1000978

About the Authors

Cristina Marino Buslje, Elin Teppa
Fundación Instituto Leloir, Buenos Aires, Argentina
Tomas Di Doménico, José María Delfino
Institute of Biochemistry and Biophysics (IQUIFIB), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Morten Nielsen
Center for Biological Sequence Analysis, Department of Systems Biology, The Technical University of Denmark, Lyngby, Denmark

Corresponding Author

Email: cmb@leloir.org.ar

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CMB MN. Performed the experiments: CMB ET TDD MN. Analyzed the data: CMB ET TDD MN. Contributed reagents/materials/analysis tools: CMB MN. Wrote the paper: CMB ET JMD MN.