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Research Article

Systematic Inference of Copy-Number Genotypes from Personal Genome Sequencing Data Reveals Extensive Olfactory Receptor Gene Content Diversity

  • Sebastian M. Waszak,

    Affiliations: Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel, Department of Biotechnology and Bioinformatics, Weihenstephan-Triesdorf University of Applied Sciences, Freising, Germany, Genome Biology Research Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Yehudit Hasin,

    Affiliation: Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel

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  • Thomas Zichner,

    Affiliation: Genome Biology Research Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Tsviya Olender,

    Affiliation: Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel

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  • Ifat Keydar,

    Affiliation: Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel

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  • Miriam Khen,

    Affiliation: Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel

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  • Adrian M. Stütz,

    Affiliation: Genome Biology Research Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Andreas Schlattl,

    Affiliation: Genome Biology Research Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Doron Lancet,

    Affiliation: Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel

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  • Jan O. Korbel mail

    jan.korbel@embl.de

    Affiliations: Genome Biology Research Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, European Bioinformatics Institute, EMBL-EBI, Hinxton, United Kingdom

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  • Published: November 11, 2010
  • DOI: 10.1371/journal.pcbi.1000988

About the Authors

Sebastian M. Waszak, Yehudit Hasin, Tsviya Olender, Ifat Keydar, Miriam Khen, Doron Lancet
Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel
Sebastian M. Waszak
Department of Biotechnology and Bioinformatics, Weihenstephan-Triesdorf University of Applied Sciences, Freising, Germany
Sebastian M. Waszak, Thomas Zichner, Adrian M. Stütz, Andreas Schlattl, Jan O. Korbel
Genome Biology Research Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Jan O. Korbel
European Bioinformatics Institute, EMBL-EBI, Hinxton, United Kingdom

Corresponding Author

Email: jan.korbel@embl.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SMW DL JOK. Performed the experiments: YH MK AMS. Analyzed the data: SMW YH TZ TO IK AS JOK. Wrote the paper: SMW YH DL JOK. Designed and implemented the CopySeq software: SMW.