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Research Article

Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology

  • Theresa M. Yuraszeck,

    Affiliation: Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California, United States of America

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  • Pierre Neveu,

    Affiliations: Kavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, California, United States of America, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California, United States of America

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  • Maria Rodriguez-Fernandez,

    Affiliation: Process Engineering Group, IIM-CSIC, Spanish Council for Scientific Research, Vigo, Spain

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  • Anne Robinson,

    Affiliation: Department of Chemical Engineering, University of Delaware, Newark, Delaware, United States of America

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  • Kenneth S. Kosik,

    Affiliations: Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California, United States of America, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, United States of America

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  • Francis J. Doyle III mail

    frank.doyle@icb.ucsb.edu

    Affiliations: Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California, United States of America, Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, California, United States of America

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  • Published: November 11, 2010
  • DOI: 10.1371/journal.pcbi.1000997

About the Authors

Theresa M. Yuraszeck, Francis J. Doyle III
Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California, United States of America
Pierre Neveu
Kavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, California, United States of America
Pierre Neveu, Kenneth S. Kosik
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California, United States of America
Maria Rodriguez-Fernandez
Process Engineering Group, IIM-CSIC, Spanish Council for Scientific Research, Vigo, Spain
Anne Robinson
Department of Chemical Engineering, University of Delaware, Newark, Delaware, United States of America
Kenneth S. Kosik
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, United States of America
Francis J. Doyle III
Institute for Collaborative Biotechnologies, University of California, Santa Barbara, Santa Barbara, California, United States of America

Corresponding Author

Email: frank.doyle@icb.ucsb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AR KSK FJD. Performed the experiments: TMY MRF. Analyzed the data: TMY PN MRF. Wrote the paper: TMY. Experiments are in silico: TMY.