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Research Article

How Cations Can Assist DNase I in DNA Binding and Hydrolysis

  • Marc Guéroult,

    Affiliations: CNRS UPR 9080, Institut de Biologie Physico-Chimique, Paris, France, INTS, INSERM UMR S665, Paris, France

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  • Daniel Picot,

    Affiliation: CNRS UMR 7099, Institut de Biologie Physico-Chimique, Paris, France

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  • Joséphine Abi-Ghanem,

    Affiliation: INTS, INSERM UMR S665, Paris, France

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  • Brigitte Hartmann mail,

    brigitte.hartmann@univ-paris-diderot.fr. (BH); baaden@smplinux.de (MB)

    Affiliation: INTS, INSERM UMR S665, Paris, France

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  • Marc Baaden mail

    brigitte.hartmann@univ-paris-diderot.fr. (BH); baaden@smplinux.de (MB)

    Affiliation: CNRS UPR 9080, Institut de Biologie Physico-Chimique, Paris, France

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  • Published: November 18, 2010
  • DOI: 10.1371/journal.pcbi.1001000

About the Authors

Marc Guéroult, Marc Baaden
CNRS UPR 9080, Institut de Biologie Physico-Chimique, Paris, France
Marc Guéroult, Joséphine Abi-Ghanem, Brigitte Hartmann
INTS, INSERM UMR S665, Paris, France
Daniel Picot
CNRS UMR 7099, Institut de Biologie Physico-Chimique, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BH MB. Performed the experiments: MG JAG. Analyzed the data: MG DP BH MB. Contributed reagents/materials/analysis tools: MG DP BH MB. Wrote the paper: MG BH MB. Crystallographic expertise and analysis of the data: DP.