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Research Article

Treatment-Mediated Alterations in HIV Fitness Preserve CD4+ T Cell Counts but Have Minimal Effects on Viral Load

  • Naveen K. Vaidya,

    Affiliation: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Libin Rong,

    Affiliation: Department of Mathematics and Statistics, Oakland University, Rochester, Michigan, United States of America

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  • Vincent C. Marconi,

    Affiliation: Emory University School of Medicine, Division of Infectious Diseases, Atlanta, Georgia, United States of America

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  • Daniel R. Kuritzkes,

    Affiliation: Section of Retroviral Therapeutics, Brigham and Women's Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Steven G. Deeks,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, San Francisco General Hospital, San Francisco, California, United States of America

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  • Alan S. Perelson mail

    asp@lanl.gov

    Affiliation: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Published: November 24, 2010
  • DOI: 10.1371/journal.pcbi.1001012

About the Authors

Naveen K. Vaidya, Alan S. Perelson
Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Libin Rong
Department of Mathematics and Statistics, Oakland University, Rochester, Michigan, United States of America
Vincent C. Marconi
Emory University School of Medicine, Division of Infectious Diseases, Atlanta, Georgia, United States of America
Daniel R. Kuritzkes
Section of Retroviral Therapeutics, Brigham and Women's Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
Steven G. Deeks
Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
Steven G. Deeks
San Francisco General Hospital, San Francisco, California, United States of America

Corresponding Author

Email: asp@lanl.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NKV SGD ASP. Performed the experiments: NKV LR SGD. Analyzed the data: NKV. Contributed reagents/materials/analysis tools: VCM DRK SGD. Wrote the paper: NKV LR VCM DRK SGD ASP.