Advertisement
Research Article

Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

  • John C. Panetta mail,

    carl.panetta@stjude.org

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Alex Sparreboom,

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Ching-Hon Pui,

    Affiliations: Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Mary V. Relling,

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • William E. Evans

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Published: December 02, 2010
  • DOI: 10.1371/journal.pcbi.1001019

About the Authors

John C. Panetta, Alex Sparreboom, Mary V. Relling, William E. Evans
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
John C. Panetta, Alex Sparreboom, Ching-Hon Pui, Mary V. Relling, William E. Evans
Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America
Ching-Hon Pui
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Corresponding Author

Email: carl.panetta@stjude.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHP MVR WEE. Performed the experiments: CHP MVR WEE. Analyzed the data: JCP. Wrote the paper: JCP AS CHP MVR WEE.