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Research Article

The Evolutionary Analysis of Emerging Low Frequency HIV-1 CXCR4 Using Variants through Time—An Ultra-Deep Approach

  • John Archer,

    Affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Andrew Rambaut,

    Affiliation: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Bruce E. Taillon,

    Affiliation: 454 Life Sciences, Branford, Connecticut, United States of America

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  • P. Richard Harrigan,

    Affiliations: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Marilyn Lewis,

    Affiliation: Pfizer Global Research and Development, Sandwich, United Kingdom

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  • David L. Robertson mail

    david.robertson@manchester.ac.uk

    Affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Published: December 16, 2010
  • DOI: 10.1371/journal.pcbi.1001022

About the Authors

John Archer, David L. Robertson
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Andrew Rambaut
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
Bruce E. Taillon
454 Life Sciences, Branford, Connecticut, United States of America
P. Richard Harrigan
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada
P. Richard Harrigan
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Marilyn Lewis
Pfizer Global Research and Development, Sandwich, United Kingdom

Corresponding Author

Email: david.robertson@manchester.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML DLR. Performed the experiments: JA BET PRH. Analyzed the data: JA DLR. Contributed reagents/materials/analysis tools: AR. Wrote the paper: JA ML DLR.