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Research Article

A Systems Model for Immune Cell Interactions Unravels the Mechanism of Inflammation in Human Skin

  • Najl V. Valeyev equal contributor mail,

    equal contributor Contributed equally to this work with: Najl V. Valeyev, Christian Hundhausen

    N.Valeyev@kent.ac.uk

    Affiliation: St. John's Institute of Dermatology, King's College London, London, United Kingdom

    Current address: Centre for Molecular Processing, School of Biosciences, University of Kent, Canterbury, United Kingdom.

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  • Christian Hundhausen equal contributor,

    equal contributor Contributed equally to this work with: Najl V. Valeyev, Christian Hundhausen

    Affiliation: St. John's Institute of Dermatology, King's College London, London, United Kingdom

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  • Yoshinori Umezawa,

    Affiliation: St. John's Institute of Dermatology, King's College London, London, United Kingdom

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  • Nikolay V. Kotov,

    Affiliation: Biophysics and Bionics Lab, Department of Physics, Kazan State University, Kazan, Russia

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  • Gareth Williams,

    Affiliation: Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom

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  • Alex Clop,

    Affiliation: Department of Medical and Molecular Genetics, King's College London, London, United Kingdom

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  • Crysanthi Ainali,

    Affiliations: St. John's Institute of Dermatology, King's College London, London, United Kingdom, Centre for Bioinformatics, Department of Computer Science, School of Physical Sciences & Engineering, King's College London, London, United Kingdom

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  • Christos Ouzounis,

    Affiliation: Centre for Bioinformatics, Department of Computer Science, School of Physical Sciences & Engineering, King's College London, London, United Kingdom

    Current address: Institute of Agrobiotechnology, CERTH, Thessalonica, Greece.

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  • Sophia Tsoka,

    Affiliation: Centre for Bioinformatics, Department of Computer Science, School of Physical Sciences & Engineering, King's College London, London, United Kingdom

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  • Frank O. Nestle

    Affiliation: St. John's Institute of Dermatology, King's College London, London, United Kingdom

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  • Published: December 02, 2010
  • DOI: 10.1371/journal.pcbi.1001024

About the Authors

Najl V. Valeyev, Christian Hundhausen, Yoshinori Umezawa, Crysanthi Ainali, Frank O. Nestle
St. John's Institute of Dermatology, King's College London, London, United Kingdom
Nikolay V. Kotov
Biophysics and Bionics Lab, Department of Physics, Kazan State University, Kazan, Russia
Gareth Williams
Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom
Alex Clop
Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
Crysanthi Ainali, Christos Ouzounis, Sophia Tsoka
Centre for Bioinformatics, Department of Computer Science, School of Physical Sciences & Engineering, King's College London, London, United Kingdom

Corresponding Author

Email: N.Valeyev@kent.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NVV CH YU NVK GW AC. Performed the experiments: CH YU NVK. Analyzed the data: NVV CH YU NVK GW AC CA CO ST. Contributed reagents/materials/analysis tools: FON. Wrote the paper: NVV CH YU NVK AC FON.