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Research Article

Modeling the Evolution of Regulatory Elements by Simultaneous Detection and Alignment with Phylogenetic Pair HMMs

  • William H. Majoros mail,

    bmajoros@duke.edu (WHM); uwe.ohler@duke.edu (UO)

    Affiliation: Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina, United States of America

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  • Uwe Ohler mail

    bmajoros@duke.edu (WHM); uwe.ohler@duke.edu (UO)

    Affiliations: Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina, United States of America, Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, United States of America

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  • Published: December 16, 2010
  • DOI: 10.1371/journal.pcbi.1001037

About the Authors

William H. Majoros, Uwe Ohler
Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina, United States of America
Uwe Ohler
Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WHM UO. Performed the experiments: WHM. Analyzed the data: WHM UO. Wrote the paper: WHM UO.