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Research Article

Phase-Locked Signals Elucidate Circuit Architecture of an Oscillatory Pathway

  • Andreja Jovic,

    Affiliation: Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Bryan Howell,

    Affiliation: Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Michelle Cote,

    Affiliation: Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Susan M. Wade,

    Affiliation: Pharmacology Department, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Khamir Mehta,

    Affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Atsushi Miyawaki,

    Affiliation: Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, Wako City, Saitama, Japan

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  • Richard R. Neubig,

    Affiliation: Pharmacology Department, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jennifer J. Linderman mail,

    takayama@umich.edu (ST); linderma@umich.edu (JJL)

    Affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Shuichi Takayama mail

    takayama@umich.edu (ST); linderma@umich.edu (JJL)

    Affiliations: Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America, Macromolecular Science and Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: December 23, 2010
  • DOI: 10.1371/journal.pcbi.1001040

About the Authors

Andreja Jovic, Bryan Howell, Michelle Cote, Shuichi Takayama
Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America
Susan M. Wade, Richard R. Neubig
Pharmacology Department, University of Michigan, Ann Arbor, Michigan, United States of America
Khamir Mehta, Jennifer J. Linderman
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
Atsushi Miyawaki
Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, Wako City, Saitama, Japan
Shuichi Takayama
Macromolecular Science and Engineering Department, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJ JJL ST. Performed the experiments: AJ MC. Analyzed the data: AJ BH MC KM JJL ST. Contributed reagents/materials/analysis tools: AJ SMW AM RRN ST. Wrote the paper: AJ JJL ST.