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Research Article

A Novel Approach to Pharmacodynamic Assessment of Antimicrobial Agents: New Insights to Dosing Regimen Design

  • Vincent H. Tam mail,

    vtam@uh.edu

    Affiliations: Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Houston, Texas, United States of America, Department of Chemical and Biomolecular Engineering, Cullen College of Engineering, University of Houston, Houston, Texas, United States of America

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  • Michael Nikolaou

    Affiliation: Department of Chemical and Biomolecular Engineering, Cullen College of Engineering, University of Houston, Houston, Texas, United States of America

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  • Published: January 06, 2011
  • DOI: 10.1371/journal.pcbi.1001043

About the Authors

Vincent H. Tam
Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Houston, Texas, United States of America
Vincent H. Tam, Michael Nikolaou
Department of Chemical and Biomolecular Engineering, Cullen College of Engineering, University of Houston, Houston, Texas, United States of America

Corresponding Author

Email: vtam@uh.edu

Competing Interests

Vincent H. Tam has received unrestricted research grants from Achaogen, AstraZeneca and Merck. He has also received speaking honoraria from Merck. Michael Nikolaou: none to declare.

Author Contributions

Conceived and designed the experiments: VHT MN. Performed the experiments: VHT. Analyzed the data: VHT MN. Contributed reagents/materials/analysis tools: MN. Wrote the paper: VHT.