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Research Article

A Comprehensive Model of the Spatio-Temporal Stem Cell and Tissue Organisation in the Intestinal Crypt

  • Peter Buske equal contributor mail,

    equal contributor Contributed equally to this work with: Peter Buske, Jörg Galle

    buske@izbi.uni-leipzig.de

    Affiliation: Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany

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  • Jörg Galle equal contributor,

    equal contributor Contributed equally to this work with: Peter Buske, Jörg Galle

    Affiliation: Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany

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  • Nick Barker,

    Affiliation: Hubrecht Institute, University Medical Center, Utrecht, The Netherlands

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  • Gabriela Aust,

    Affiliation: Center of Surgery, Research Laboratories, University Leipzig, Leipzig, Germany

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  • Hans Clevers,

    Affiliation: Hubrecht Institute, University Medical Center, Utrecht, The Netherlands

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  • Markus Loeffler

    Affiliations: Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany, Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, Leipzig, Germany

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  • Published: January 06, 2011
  • DOI: 10.1371/journal.pcbi.1001045

About the Authors

Peter Buske, Jörg Galle, Markus Loeffler
Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany
Nick Barker, Hans Clevers
Hubrecht Institute, University Medical Center, Utrecht, The Netherlands
Gabriela Aust
Center of Surgery, Research Laboratories, University Leipzig, Leipzig, Germany
Markus Loeffler
Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, Leipzig, Germany

Corresponding Author

Email: buske@izbi.uni-leipzig.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NB HC. Performed the experiments: NB GA. Analyzed the data: PB JG. Wrote the paper: JG ML. Performed all simulations: PB. Designed the model: JG. Provided essential ideas regarding the model design: HC ML.