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Research Article

Gene Expression Noise in Spatial Patterning: hunchback Promoter Structure Affects Noise Amplitude and Distribution in Drosophila Segmentation

  • David M. Holloway mail,

    David_Holloway@bcit.ca

    Affiliations: Mathematics Department, British Columbia Institute of Technology, Burnaby, British Columbia, Canada, Biology Department, University of Victoria, Victoria, British Columbia, Canada

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  • Francisco J. P. Lopes,

    Affiliation: Instituto de Biofisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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  • Luciano da Fontoura Costa,

    Affiliation: Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Sao Paulo, Brazil

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  • Bruno A. N. Travençolo,

    Affiliations: Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Sao Paulo, Brazil, Faculty of Computing, Federal University of Uberlândia, Uberlândia, Brazil

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  • Nina Golyandina,

    Affiliation: Mathematics and Mechanics Faculty, St. Petersburg State University, St. Petersburg, Russia

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  • Konstantin Usevich,

    Affiliation: Mathematics and Mechanics Faculty, St. Petersburg State University, St. Petersburg, Russia

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  • Alexander V. Spirov

    Affiliation: Computer Science and Center of Excellence in Wireless and Information Technology, Stony Brook University, Stony Brook, New York, United States of America

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  • Published: February 03, 2011
  • DOI: 10.1371/journal.pcbi.1001069

About the Authors

David M. Holloway
Mathematics Department, British Columbia Institute of Technology, Burnaby, British Columbia, Canada
David M. Holloway
Biology Department, University of Victoria, Victoria, British Columbia, Canada
Francisco J. P. Lopes
Instituto de Biofisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Luciano da Fontoura Costa, Bruno A. N. Travençolo
Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Sao Paulo, Brazil
Bruno A. N. Travençolo
Faculty of Computing, Federal University of Uberlândia, Uberlândia, Brazil
Nina Golyandina, Konstantin Usevich
Mathematics and Mechanics Faculty, St. Petersburg State University, St. Petersburg, Russia
Alexander V. Spirov
Computer Science and Center of Excellence in Wireless and Information Technology, Stony Brook University, Stony Brook, New York, United States of America

Corresponding Author

Email: David_Holloway@bcit.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMH FJPL AVS. Performed the experiments: DMH FJPL AVS. Analyzed the data: DMH FJPL LdFC BANT NG KU AVS. Contributed reagents/materials/analysis tools: DMH FJPL LdFC BANT NG KU AVS. Wrote the paper: DMH FJPL AVS.