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Research Article

Dynamically-Driven Inactivation of the Catalytic Machinery of the SARS 3C-Like Protease by the N214A Mutation on the Extra Domain

  • Jiahai Shi equal contributor,

    equal contributor Contributed equally to this work with: Jiahai Shi, Nanyu Han

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • Nanyu Han equal contributor,

    equal contributor Contributed equally to this work with: Jiahai Shi, Nanyu Han

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Liangzhong Lim,

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • Shixiong Lua,

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • J. Sivaraman,

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • Lushan Wang,

    Affiliation: State Key Laboratory of Microbial Technology, Shandong University, Jinan, China

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  • Yuguang Mu mail,

    bchsj@nus.edu.sg (JS); YGMu@ntu.edu.sg (YM)

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Jianxing Song mail

    bchsj@nus.edu.sg (JS); YGMu@ntu.edu.sg (YM)

    Affiliations: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine and National University of Singapore, Singapore

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  • Published: February 24, 2011
  • DOI: 10.1371/journal.pcbi.1001084

About the Authors

Jiahai Shi, Liangzhong Lim, Shixiong Lua, J. Sivaraman, Jianxing Song
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
Nanyu Han, Yuguang Mu
School of Biological Sciences, Nanyang Technological University, Singapore
Lushan Wang
State Key Laboratory of Microbial Technology, Shandong University, Jinan, China
Jianxing Song
Department of Biochemistry, Yong Loo Lin School of Medicine and National University of Singapore, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: J. Shi, Y. Mu, J. Song. Performed the experiments: J. Shi, N. Han, Y. Mu, J. Song. Analyzed the data: J. Shi, N. Han, L. Lim, Y. Mu, J. Song. Contributed reagents/materials/analysis tools: S. Lua, J. Sivaraman, L. Wang, Y. Mu, J. Song. Wrote the paper: J. Shi, Y. Mu, J. Song.