Advertisement
Research Article

Molecular Dynamics Simulations of Forced Unbending of Integrin αVβ3

  • Wei Chen,

    Affiliation: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    Current address: Department of Bioengineering, University of Washington, Seattle, Washington, United States of America

    X
  • Jizhong Lou,

    Affiliation: Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    Current address: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    X
  • Jen Hsin,

    Affiliation: Department of Physics and Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Klaus Schulten,

    Affiliation: Department of Physics and Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Stephen C. Harvey,

    Affiliations: Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America, School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    X
  • Cheng Zhu mail

    cheng.zhu@bme.gatech.edu

    Affiliations: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    X
  • Published: February 17, 2011
  • DOI: 10.1371/journal.pcbi.1001086

About the Authors

Wei Chen, Cheng Zhu
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Jizhong Lou, Stephen C. Harvey, Cheng Zhu
Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Jen Hsin, Klaus Schulten
Department of Physics and Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Stephen C. Harvey
School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Cheng Zhu
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Corresponding Author

Email: cheng.zhu@bme.gatech.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WC JL CZ. Performed the experiments: WC JH. Analyzed the data: WC JH. Wrote the paper: WC JL CZ. Provided computational resources: CZ KS SCH.