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Research Article

Self-Organization of Muscle Cell Structure and Function

  • Anna Grosberg equal contributor,

    equal contributor Contributed equally to this work with: Anna Grosberg, Po-Ling Kuo

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Po-Ling Kuo equal contributor,

    equal contributor Contributed equally to this work with: Anna Grosberg, Po-Ling Kuo

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Chin-Lin Guo,

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Nicholas A. Geisse,

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Mark-Anthony Bray,

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • William J. Adams,

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Sean P. Sheehy,

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Kevin Kit Parker mail

    kkparker@seas.harvard.edu

    Affiliation: Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Published: February 24, 2011
  • DOI: 10.1371/journal.pcbi.1001088

About the Authors

Anna Grosberg, Po-Ling Kuo, Chin-Lin Guo, Nicholas A. Geisse, Mark-Anthony Bray, William J. Adams, Sean P. Sheehy, Kevin Kit Parker
Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: kkparker@seas.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PLK CLG KKP. Performed the experiments: PLK NAG. Analyzed the data: PLK MAB. Contributed reagents/materials/analysis tools: SPS. Wrote the paper: AG PLK CLG KKP. Designed and implemented the model and in silico experiments: AG. Co-developed the math model: CLG, PLK, KKP. Provided important technological contributions to experimental techniques: WJA. Contributed important cell culture design and support: SPS.