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Research Article

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain

  • Vitaly A. Selivanov,

    Affiliations: Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, and IBUB, Barcelona, Spain, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

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  • Tatyana V. Votyakova mail,

    tav2@pitt.edu (TVV); martacascante@ub.edu (MC)

    Affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Diabetes Institute, Pittsburgh, Pennsylvania, United States of America

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  • Violetta N. Pivtoraiko,

    Affiliation: Neuropathology Division, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Jennifer Zeak,

    Affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Diabetes Institute, Pittsburgh, Pennsylvania, United States of America

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  • Tatiana Sukhomlin,

    Affiliation: Institute of Theoretical and Experimental Biophysics, Pushchino, Russia

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  • Massimo Trucco,

    Affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Diabetes Institute, Pittsburgh, Pennsylvania, United States of America

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  • Josep Roca,

    Affiliation: Hospital Clinic, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Catalunya, Spain

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  • Marta Cascante mail

    tav2@pitt.edu (TVV); martacascante@ub.edu (MC)

    Affiliation: Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, and IBUB, Barcelona, Spain

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  • Published: March 31, 2011
  • DOI: 10.1371/journal.pcbi.1001115

About the Authors

Vitaly A. Selivanov, Marta Cascante
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, and IBUB, Barcelona, Spain
Vitaly A. Selivanov
A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia
Tatyana V. Votyakova, Jennifer Zeak, Massimo Trucco
Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Diabetes Institute, Pittsburgh, Pennsylvania, United States of America
Violetta N. Pivtoraiko
Neuropathology Division, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Tatiana Sukhomlin
Institute of Theoretical and Experimental Biophysics, Pushchino, Russia
Josep Roca
Hospital Clinic, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Catalunya, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VAS TVV. Performed the experiments: TVV VNP JZ. Analyzed the data: VAS TS MT JR MC. Contributed reagents/materials/analysis tools: VAS. Wrote the paper: VAS TVV.