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Research Article

Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study

  • Elijah Roberts,

    Affiliations: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Andrew Magis,

    Affiliation: Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Julio O. Ortiz,

    Affiliation: Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsreid, Germany

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  • Wolfgang Baumeister,

    Affiliation: Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsreid, Germany

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  • Zaida Luthey-Schulten mail

    zan@illinois.edu

    Affiliations: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Published: March 10, 2011
  • DOI: 10.1371/journal.pcbi.1002010

About the Authors

Elijah Roberts, Zaida Luthey-Schulten
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Elijah Roberts, Zaida Luthey-Schulten
Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Andrew Magis, Zaida Luthey-Schulten
Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Julio O. Ortiz, Wolfgang Baumeister
Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsreid, Germany

Corresponding Author

Email: zan@illinois.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ER AM JOO WB ZLS. Performed the experiments: ER AM JOO. Analyzed the data: ER AM JOO ZLS. Wrote the paper: ER ZLS.