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Research Article

“Fluctuograms” Reveal the Intermittent Intra-Protein Communication in Subtilisin Carlsberg and Correlate Mechanical Coupling with Co-Evolution

  • Jordi Silvestre-Ryan,

    Affiliation: Department of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America

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  • Yuchun Lin,

    Affiliation: Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California, United States of America

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  • Jhih-Wei Chu mail

    jwchu@berkeley.edu

    Affiliation: Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California, United States of America

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  • Published: March 24, 2011
  • DOI: 10.1371/journal.pcbi.1002023

About the Authors

Jordi Silvestre-Ryan
Department of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America
Yuchun Lin, Jhih-Wei Chu
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California, United States of America

Corresponding Author

Email: jwchu@berkeley.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JSR JWC. Performed the experiments: JSR YL JWC. Analyzed the data: JSR YL JWC. Contributed reagents/materials/analysis tools: JSR JWC. Wrote the paper: JSR YL JWC.