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Research Article

On the Origin of DNA Genomes: Evolution of the Division of Labor between Template and Catalyst in Model Replicator Systems

  • Nobuto Takeuchi mail,

    takeuchi@ncbi.nlm.nih.gov

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Paulien Hogeweg,

    Affiliation: Theoretical Biology and Bioinformatics Group, Utrecht University, Utrecht, The Netherlands

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  • Eugene V. Koonin

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: March 24, 2011
  • DOI: 10.1371/journal.pcbi.1002024

About the Authors

Nobuto Takeuchi, Eugene V. Koonin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
Paulien Hogeweg
Theoretical Biology and Bioinformatics Group, Utrecht University, Utrecht, The Netherlands

Corresponding Author

Email: takeuchi@ncbi.nlm.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NT PH. Performed the experiments: NT. Analyzed the data: NT. Contributed reagents/materials/analysis tools: NT. Wrote the manuscript: NT PH EVK. Interpreted the results: NT PH EVK.