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Research Article

A Mathematical Framework for Estimating Pathogen Transmission Fitness and Inoculum Size Using Data from a Competitive Mixtures Animal Model

  • James M. McCaw mail,

    jamesm@unimelb.edu.au

    Affiliations: Vaccine and Immunisation Research Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia, Melbourne School of Population Health, The University of Melbourne, Victoria, Australia

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  • Nimalan Arinaminpathy,

    Affiliation: Department of Ecology and Evolutionary Ecology, Princeton University, New Jersey, United States of America

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  • Aeron C. Hurt,

    Affiliation: WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia

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  • Jodie McVernon,

    Affiliations: Vaccine and Immunisation Research Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia, Melbourne School of Population Health, The University of Melbourne, Victoria, Australia

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  • Angela R. McLean

    Affiliation: Institute for Emerging Infections, Department of Zoology, University of Oxford, Oxford Martin School, Oxford, United Kingdom

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  • Published: April 28, 2011
  • DOI: 10.1371/journal.pcbi.1002026

About the Authors

James M. McCaw, Jodie McVernon
Vaccine and Immunisation Research Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
James M. McCaw, Jodie McVernon
Melbourne School of Population Health, The University of Melbourne, Victoria, Australia
Nimalan Arinaminpathy
Department of Ecology and Evolutionary Ecology, Princeton University, New Jersey, United States of America
Aeron C. Hurt
WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia
Angela R. McLean
Institute for Emerging Infections, Department of Zoology, University of Oxford, Oxford Martin School, Oxford, United Kingdom

Corresponding Author

Email: jamesm@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMM, ACH, JM. Performed the experiments: JMM, ACH. Analyzed the data: JMM, NA, JM, ARM. Contributed reagents/materials/analysis tools: ACH. Wrote the paper: JMM. Contributed to mathematical algorithms: JMM, NA, JM, ARM.